ACTIVITY OF BLUTAPARONPORTULACOIDES ETHANOLIC EXTRACT IN INFLAMATORY REACTION, DEPRESSION AND ANXIETY IN MICE

Resumo

Introduction: Humans have used plants to treat  several diseases. Blutaparonportulacoides, belongs to the Amaranthaceae family, Magnoliopsida class, Caryophyllales order, characterized by A. L. Jussieu in 1789. In Brazil it occurs in Atlantic Forest.1 Several plant species are used in Brazilian traditional communities and the pharmaological studies of plants extracts, fractions or product-derived are necessary to know new medicines for inflammatory, depressive and anxiety diseases treatment. Objectives: In this study, we examined the activity of aerial B.portulacoidesethanolic extract in inflammatory process, depressionand anxietyin mice. Methods: Swissmice(20 to25g) were randomly divided into groups treated with diazepan(positive control group)(1 mg/kgdose, intraperitoneal route), vehicle(control group)(oral administration), and treatment with extract (250 mg/kg, oral administration). After 30 min from oral or intraperitoneal injection, the animals were submitted to marble buryingand tail suspension test. Four hours after gavage, we did carrageenan-induced pleurisy model (Solution containing 1% of carrageenan) .To evaluation of inflammatory reaction, leukocytes influx in the pleural cavity, total cell and differential leukocyte counts were performed. Results/discussion: The total leukocytes, but not the observation in tail suspension (depression) or marble burying (anxiety test),significantly decreased in animals treated with extract, when compared to control animals. In marble buryingtest the control group(G1), burried approximately 10 marbles while theB. portulacoides(G2), burried 10 marbles; and the group diazepan(G3), burried 3 marbles. In the tail suspension test (G2) remainedin the state ofimmobilityapproximately147 seconds (G1)stood still for 95 seconds in the state of immobility and since G3 stood about300segundos. Conclusion: From the results obtained, it was shown that Blutaparonportulacoidesis able to reduce inflammatory reaction but no depression behavior and nor anxiety were significantly.